Jurgen Klopp‘s dominant crop are already assured of their place in the last 16, while the Rossoneri are involved in a three-way battle for second place in Group B.
Liverpool came up trumps in a 3-2 thriller with AC Milan during September’s battle at Anfield, but the 2005 and 2007 finalists have never locked horns at the inimitable San Siro before.
Milan’s attacking forces have taken quite the hit in recent weeks, with Olivier Giroud, Samu Castillejo and Ante Rebic being joined in the medical bay by Pietro Pellegri, who came off after 15 minutes against Salernitana on Saturday with a groin issue.
Zlatan Ibrahimovic is therefore sure to lead the line after being rested at the weekend.
An inexperienced Liverpool side playing on the San Siro turf for the first time may just come up short this week, especially with Pioli’s side having much more to fight for in midweek.
AC Milan can follow up their hard-fought Wanda Metropolitano win with a victory that may or may not be enough for a spot in the knockout rounds.